Table 1.

Estimates of relative fitness and epistatic deviations of different genotypes.

progenitor strainmutations addedfitness relative to progenitor (95% CI)absolute epistasis (95% CI)maximum growth rate of progenitor (per hour) (s.e.m.)
ECOR1topA1.010 (0.082)
pykF1.120 (0.082)
topA, pykF1.060 (0.074)−0.076 (0.193)0.654 (0.016)
VS-126topA1.160 (0.033)
pykF1.284 (0.078)
topA, pykF1.255 (0.109)−0.233 (0.085)0.663 (0.021)
VS-820topA0.988 (0.035)
pykF1.029 (0.074)
topA, pykF1.022 (0.028)0.006 (0.035)0.612 (0.065)
TA135topA1.171 (0.087)
pykF1.279 (0.181)
topA, pykF1.268 (0.058)−0.226 (0.111)0.700 (0.069)
R424topA0.998 (0.080)
pykF1.173 (0.114)
topA, pykF1.089 (0.048)−0.081 (0.131)0.587 (0.005)
E267topA1.383 (0.042)
pykF1.054 (0.098)
topA, pykF1.428 (0.043)−0.031 (0.116)0.618 (0.031)
TA105topA1.130 (0.065)
pykF1.157 (0.244)
topA, pykF1.087 (0.112)−0.225 (0.219)0.726 (0.037)
REL606topA1.142 (0.023)
pykF1.000 (0.013)
topA, pykF1.193 (0.023)0.051 (0.051)0.591 (0.014)